The community of Orange Farm, south of Johannesburg says it fears there may be a syndicate targeting children operating in the area.
The concern follows after the deaths of two more children in the area last week.
Eight-year-old Nkosinathi and seven-year-old Sbongiseni died minutes apart from each other.
Their families believe the children were poisoned.
According to witnesses, two men were seen giving one of the children a yogurt to eat before they got sick.
MMC for community safety in Joburg Margret Arnolds says six children have died in the area under similar circumstances.
The Gauteng Department of Community Safety says it will be providing assistance to the families of the two boys.
Last month, the community called on Police Minister, Bheki Cele, to close down the local police station because they are ineffective.
MMC for community safety in Joburg Margret Arnolds says the minister needs to speed up the process to find solutions in the Orange Farm area.
Last year the community of Orange Farm was left reeling after two children were found dead after going missing.
#sapsGP Police investigating the death of 2 children after they were reported missing a few hours prior to the discovery of their bodies in Orange Farm. Anyone with information is urged to call #CrimeStop 08600 10111 or use #MySAPSApp to submit tip-off. NPhttps://t.co/QHffE9lOP6 pic.twitter.com/gjqFH4oZQk
— SA Police Service 🇿🇦 (@SAPoliceService) September 19, 2020